What are the biomarkers for sepsis? Any specific lab founding?
Various biomarkers have been evaluated and studied nowadays for the accuracy diagnose of Sepsis. Until now, there are four biomarkers for sepsis: Procalcitonin, c-reactive Protein ( CRP ), B-Type Natriuretic Peptide and Protein C. Some studies proofed that Procalcitonin and CRP is the most widely use for diagnosing sepsis patients.Mechanism of disease: How is the actual process of this disease? What happened to our body? To simplified what really happened to our body when weâ€™re diagnosed with Sepsis is that it is an exaggerated inflammation, complex reaction between: microbe (infectious agent) , host immune respond (our immune system), the inflammatory process itself and the coagulation pathway. This abnormality process makes various effects on the body system, especially Coagulation system. This will produced many problematic in blood clotting times, internal bleeding and global microvascular thrombosis. Worst case scenario, it could lead into Multi organ Dysfunction or multi organ failure. The Protein C pathway usually inhibits thrombosis and inflammation, it serves the coagulation system, promoting fibrinolysis. When sepsis happened, it will changed and disturbing this protein pathway so that produced many problem and symptom in our body.